At the end of Legion, the titan Sargeras was imprisoned, but not before he plunged his sword into the planet Azeroth. This not only devastated a massive area (much of the desert zone of Silithus is now cracked and scorched), but badly wounded the gestating titan inside. While the heroes managed to ablate the worst of the damage (at the cost of the majority of their artifact weapons' mythic power), the world is still wounded and bleeding a substance called "Azerite," which has great magical potential. The Horde Warchief, Sylvanas Windrunner, attempts to consolidate Horde power on Kalimdor and gain a monopoly on Azerite (which is primarily found at the southern end of the continent). Her campaign to do so, the War of Thorns, formed a pre-launch event for the expansion and ends with the major Night Elf holdings on the continent seized or (in the case of their capital city of Darnassus) annihilated. The Alliance makes a retaliatory strike against her home base, the Undercity, which was formerly the human capital of Lordaeron. This succeeds in driving the Horde out, but before leaving Sylvanas saturates the area with disease and toxins that render it uninhabitable. With this tit-for-tat military exchange, the Horde has almost complete control over Kalimdor, while the Alliance has near-total dominion over the Eastern Kingdoms. With further conflict inevitable, Battle for Azeroth takes the two factions to the continents of Kul Tiras and Zandalar to recruit new allies in order to turn the tides of war.
Chilled to the Bone, Dampened Magic, Kleptomania, Netherwind Armor, Prismatic Cloak, and Temporal Shield have limited use in PvE content in terms of increasing your damage in the open world, but they can be situationally useful. Notably Temporal Shield can be utilized for, functionally, an extra 6 seconds of combat time against large elite mobs.